hypoxic$37119$ - vertaling naar italiaans
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hypoxic$37119$ - vertaling naar italiaans

HYPOXIC CONDITIONS IN TUMOR CELLS
Hypoxic tumor; Tumour hypoxia
  • Regulatory pathway of PFK-1 by fructose-2,6-bisphosphate
  • GLUT1 Glucose Transporter
  • Overview of the HIF-1 effect on the expression of glycolytic enzymes
  • HIF regulates interactions of cancer cells with ECM and ECM biosynthesis
  • The Structure of Lactic Acid
  • Schematic highlighting the metabolic symbiosis formed between hypoxic and normoxic tumor cells
  • The areas surrounding the phosphorylation sites on pyruvate dehydrogenase are shown in red. Pyruvate dehydrogenase kinase phosphorylation of these sites leads to decreased dehydrogenase activity
  • Tumour stroma and extracellular matrix in hypoxia

hypoxic      
adj. ipossico (mancante di ossigeno nel sangue)

Definitie

hypoxia
[h??'p?ks??]
¦ noun Medicine deficiency in the amount of oxygen reaching the tissues.
?Ecology oxygen deficiency in a biotic environment.
Derivatives
hypoxic adjective
Origin
1940s: from hypo- + oxygen + -ia1.

Wikipedia

Tumor hypoxia

Tumor hypoxia is the situation where tumor cells have been deprived of oxygen. As a tumor grows, it rapidly outgrows its blood supply, leaving portions of the tumor with regions where the oxygen concentration is significantly lower than in healthy tissues. Hypoxic microenvironements in solid tumors are a result of available oxygen being consumed within 70 to 150 μm of tumour vasculature by rapidly proliferating tumor cells thus limiting the amount of oxygen available to diffuse further into the tumor tissue. In order to support continuous growth and proliferation in challenging hypoxic environments, cancer cells are found to alter their metabolism. Furthermore, hypoxia is known to change cell behavior and is associated with extracellular matrix remodeling and increased migratory and metastatic behavior.